Asymmetric synthesis of cyclopropyl-fused 2'-C-methylcarbanucleosides as potential anti-HCV agents.

Jeong, Lak Shin; Lee, Jeong A; Kim, Hea Ok; Tosh, Dilip K; Moon, Hyung Ryong; Lee, Seung-Jin; Lee, Kang Man; Sheen, Yhun Y; Chun, Moon Woo

Jeong, Lak Shin; Lee, Jeong A; Kim, Hea Ok; Tosh, Dilip K; Moon, Hyung Ryong; Lee, Seung-Jin; Lee, Kang Man; Sheen, Yhun Y; Chun, Moon Woo.

Affiliation

Jeong LS; College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr

Nucleosides Nucleotides Nucleic Acids ; 26(8-9): 1021-4, 2007.

Article in En | MEDLINE | ID: mdl-18058529

ABSTRACT

ABSTRACT

Novel 2'-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

Subject(s)

Antiviral Agents/chemical synthesis; Antiviral Agents/pharmacology; Hepacivirus/drug effects; Nucleosides/chemical synthesis; Nucleosides/pharmacology; Antiviral Agents/chemistry; Drug Design; Humans; Indicators and Reagents; Nucleosides/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Hepacivirus / Nucleosides Limits: Humans Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2007 Document type: Article

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