Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel.

Surber, Ralf; Hensellek, Sabine; Prochnau, Dirk; Werner, Gerald S; Benndorf, Klaus; Figulla, Hans R; Zimmer, Thomas

Surber, Ralf; Hensellek, Sabine; Prochnau, Dirk; Werner, Gerald S; Benndorf, Klaus; Figulla, Hans R; Zimmer, Thomas.

Affiliation

Surber R; Department of Internal Medicine I, Friedrich Schiller University Jena, Jena, Germany.

Cardiovasc Res ; 77(4): 740-8, 2008 Mar 01.

Article in En | MEDLINE | ID: mdl-18065446

Subject(s)

Bundle-Branch Block/genetics; Long QT Syndrome/genetics; Muscle Proteins/genetics; Mutation; Myocardium/metabolism; Sodium Channels/genetics; Sodium/metabolism; Action Potentials; Adolescent; Adult; Ajmaline/therapeutic use; Animals; Anti-Arrhythmia Agents/therapeutic use; Bundle-Branch Block/drug therapy; Bundle-Branch Block/metabolism; Bundle-Branch Block/physiopathology; Cell Line; Child; DNA Mutational Analysis; Death, Sudden, Cardiac/etiology; Electrocardiography; Female; Gene Transfer Techniques; Genetic Predisposition to Disease; Humans; Kinetics; Lidocaine/therapeutic use; Long QT Syndrome/drug therapy; Long QT Syndrome/metabolism; Long QT Syndrome/physiopathology; Lysine; Male; Muscle Proteins/drug effects; Muscle Proteins/metabolism; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Pedigree; Sodium Channels/drug effects; Sodium Channels/metabolism; Syncope/genetics; Syncope/metabolism; Threonine; Xenopus laevis

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Collection: 01-internacional Database: MEDLINE Main subject: Sodium / Long QT Syndrome / Bundle-Branch Block / Sodium Channels / Muscle Proteins / Mutation / Myocardium Type of study: Etiology_studies Language: En Journal: Cardiovasc Res Year: 2008 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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