Low yield of screening for cryptococcal antigen by latex agglutination assay on serum and cerebrospinal fluid from Danish patients with AIDS or ARC.
Scand J Infect Dis
; 23(6): 697-702, 1991.
Article
in En
| MEDLINE
| ID: mdl-1815331
ABSTRACT
From July 1, 1989 to September 5, 1990, 530 serum specimens and 50 cerebrospinal fluid (CSF) specimens from 334 HIV-1 infected patients, most of whom had AIDS or ARC, were analysed in a cryptococcal antigen latex agglutination assay, and all were negative. Three cases of meningitis due to Cryptococcus neoformans diagnosed by microscopy and culture in 3 HIV-1 infected patients are presented. Stored specimens of serum and CSF from these patients were assayed for cryptococcal antigen, and in all 3 the onset of meningitis was preceded by the presence of cryptococcal antigen in serum. It is concluded that the low occurrence of cryptococcosis in our patient population does not justify a routine serum screening for cryptococcal antigen.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
AIDS-Related Complex
/
Acquired Immunodeficiency Syndrome
/
Meningitis, Cryptococcal
/
Cryptococcus neoformans
/
Antigens, Fungal
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Scand J Infect Dis
Year:
1991
Document type:
Article
Affiliation country:
Denmark