Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moiety.

Takamatsu, Kayo; Takano, Atsushi; Yakushiji, Nobumasa; Morishita, Ken-ichi; Matsuura, Nobuyasu; Makishima, Makoto; Ali, Hamed Ismail; Akaho, Eiichi; Tai, Akihiro; Sasaki, Kenji; Kakuta, Hiroki

Takamatsu, Kayo; Takano, Atsushi; Yakushiji, Nobumasa; Morishita, Ken-ichi; Matsuura, Nobuyasu; Makishima, Makoto; Ali, Hamed Ismail; Akaho, Eiichi; Tai, Akihiro; Sasaki, Kenji; Kakuta, Hiroki.

Affiliation

Takamatsu K; Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Okayama 700-8530, Japan.

ChemMedChem ; 3(3): 454-60, 2008 Mar.

Article in En | MEDLINE | ID: mdl-18157857

Subject(s)

Anti-Obesity Agents/pharmacology; Antineoplastic Agents/pharmacology; Cell Differentiation/drug effects; Retinoid X Receptors/agonists; Sulfonamides/pharmacology; Animals; Anti-Obesity Agents/chemical synthesis; Antineoplastic Agents/chemical synthesis; COS Cells; Cell Differentiation/physiology; Chlorocebus aethiops; Drug Synergism; Hydrophobic and Hydrophilic Interactions; Models, Chemical; Nitroblue Tetrazolium/metabolism; Oxidation-Reduction; Retinoid X Receptor alpha/agonists; Retinoid X Receptor beta/agonists; Retinoid X Receptor gamma/agonists; Sulfonamides/chemical synthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Cell Differentiation / Anti-Obesity Agents / Retinoid X Receptors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2008 Document type: Article Affiliation country: Japan Country of publication: Germany

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