DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state.

Sucato, Christopher A; Upton, Thomas G; Kashemirov, Boris A; Osuna, Jorge; Oertell, Keriann; Beard, William A; Wilson, Samuel H; Florián, Jan; Warshel, Arieh; McKenna, Charles E; Goodman, Myron F

Sucato, Christopher A; Upton, Thomas G; Kashemirov, Boris A; Osuna, Jorge; Oertell, Keriann; Beard, William A; Wilson, Samuel H; Florián, Jan; Warshel, Arieh; McKenna, Charles E; Goodman, Myron F.

Affiliation

Sucato CA; Department of Chemistry, University of Southern California, Los Angeles, California 90089, USA.

Biochemistry ; 47(3): 870-9, 2008 Jan 22.

Article in En | MEDLINE | ID: mdl-18161950

Subject(s)

Base Pair Mismatch; DNA Polymerase beta/chemistry; Catalysis; Catalytic Domain; DNA/chemistry; DNA Polymerase beta/genetics; DNA Polymerase beta/metabolism; Deoxyguanine Nucleotides/chemistry; Deuterium Oxide/chemistry; Diphosphonates/chemistry; Guanosine Triphosphate/analogs & derivatives; Halogens/chemistry; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Models, Molecular; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Substrate Specificity; Thermodynamics

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Collection: 01-internacional Database: MEDLINE Main subject: DNA Polymerase beta / Base Pair Mismatch Limits: Humans Language: En Journal: Biochemistry Year: 2008 Document type: Article Affiliation country: United States

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