Uridine supplementation antagonizes zidovudine-induced mitochondrial myopathy and hyperlactatemia in mice.

Lebrecht, Dirk; Deveaud, Catherine; Beauvoit, Bertrand; Bonnet, Jacques; Kirschner, Janbernd; Walker, Ulrich A

Lebrecht, Dirk; Deveaud, Catherine; Beauvoit, Bertrand; Bonnet, Jacques; Kirschner, Janbernd; Walker, Ulrich A.

Affiliation

Lebrecht D; Medizinische Universitätsklinik, Freiburg, Germany.

Arthritis Rheum ; 58(1): 318-26, 2008 Jan.

Article in En | MEDLINE | ID: mdl-18163507

Subject(s)

Lactates/blood; Mitochondrial Myopathies/chemically induced; Mitochondrial Myopathies/prevention & control; Reverse Transcriptase Inhibitors/toxicity; Uridine/pharmacology; Zidovudine/toxicity; Animals; DNA, Mitochondrial/metabolism; Drug Interactions; Electron Transport/drug effects; Electron Transport Complex IV/metabolism; Gene Dosage; Lipid Peroxidation/drug effects; Male; Malondialdehyde/metabolism; Mice; Mice, Inbred BALB C; Mitochondrial Myopathies/pathology; Muscle, Skeletal/pathology; Triglycerides/metabolism; Zalcitabine/toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uridine / Zidovudine / Mitochondrial Myopathies / Reverse Transcriptase Inhibitors / Lactates Limits: Animals Language: En Journal: Arthritis Rheum Year: 2008 Document type: Article Affiliation country: Germany Country of publication: United States

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