[Carbohydrate metabolism and aging--controversy of etiopathogenesis and pathophysiology. Part I. Changes of insulin sensitivity]. / Gospodarka weglowodanowa a starzenie sie organizmu--kontrowersje etiopatogenezy I patofizjologii. Czesc I. Zmiany wrazliwosci tkanek na insuline.
Wiad Lek
; 60(7-8): 386-9, 2007.
Article
in Pl
| MEDLINE
| ID: mdl-18175561
Insulin resistance is one of the reasons of increasing carbohydrate metabolism disturbances with aging. Mechanisms of these changes had been partially elucidated. Decreasing of physical activity with increasing of total and abdominal fat are especially important pathogenetic mechanisms. Changes in glucose transporter 4 (GLUT-4) level in skeletal muscles and serum level of insulin like growth factor 1 (IGF-1) could be mechanisms independent of fat tissue. Other mechanisms which could be associated with insulin resistance in aging are related to leptin and adiponectin serum level or changes in mitochondrial energy metabolism and level of advanced glucose end products in diet.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Insulin Resistance
/
Energy Metabolism
/
Carbohydrate Metabolism
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
Pl
Journal:
Wiad Lek
Journal subject:
MEDICINA
Year:
2007
Document type:
Article
Country of publication:
Poland