Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides.

Bach-Mizrachi, H; Underwood, M D; Tin, A; Ellis, S P; Mann, J J; Arango, V

Bach-Mizrachi, H; Underwood, M D; Tin, A; Ellis, S P; Mann, J J; Arango, V.

Affiliation

Bach-Mizrachi H; Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA.

Mol Psychiatry ; 13(5): 507-13, 465, 2008 May.

Article in En | MEDLINE | ID: mdl-18180753

Subject(s)

Depressive Disorder/enzymology; Nerve Tissue Proteins/physiology; Neurons/chemistry; RNA, Messenger/biosynthesis; Raphe Nuclei/chemistry; Suicide; Tryptophan Hydroxylase/physiology; Adult; Afferent Pathways/physiology; Aged; Case-Control Studies; Death, Sudden; Depressive Disorder/genetics; Female; Humans; Male; Middle Aged; Nerve Tissue Proteins/biosynthesis; Nerve Tissue Proteins/genetics; Neurons/enzymology; Prefrontal Cortex/physiopathology; RNA, Messenger/analysis; Raphe Nuclei/enzymology; Raphe Nuclei/pathology; Serotonin/physiology; Suicide/psychology; Tryptophan Hydroxylase/biosynthesis; Tryptophan Hydroxylase/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Suicide / Tryptophan Hydroxylase / RNA, Messenger / Raphe Nuclei / Depressive Disorder / Nerve Tissue Proteins / Neurons Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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