Non-charged thiamine analogs as inhibitors of enzyme transketolase.

Thomas, Allen A; De Meese, J; Le Huerou, Y; Boyd, Steven A; Romoff, Todd T; Gonzales, Steven S; Gunawardana, Indrani; Kaplan, Tomas; Sullivan, Francis; Condroski, Kevin; Lyssikatos, Joseph P; Aicher, Thomas D; Ballard, Josh; Bernat, Bryan; DeWolf, Walter; Han, May; Lemieux, Christine; Smith, Darin; Weiler, Solly; Wright, S Kirk; Vigers, Guy; Brandhuber, Barb

Thomas, Allen A; De Meese, J; Le Huerou, Y; Boyd, Steven A; Romoff, Todd T; Gonzales, Steven S; Gunawardana, Indrani; Kaplan, Tomas; Sullivan, Francis; Condroski, Kevin; Lyssikatos, Joseph P; Aicher, Thomas D; Ballard, Josh; Bernat, Bryan; DeWolf, Walter; Han, May; Lemieux, Christine; Smith, Darin; Weiler, Solly; Wright, S Kirk; Vigers, Guy; Brandhuber, Barb.

Affiliation

Thomas AA; Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, USA. athomas@arraybiopharma.com

Bioorg Med Chem Lett ; 18(2): 509-12, 2008 Jan 15.

Article in En | MEDLINE | ID: mdl-18182286

Subject(s)

Enzyme Inhibitors/pharmacology; Thiamine/analogs & derivatives; Transketolase/antagonists & inhibitors; Animals; Catalysis; Cell Line; Crystallography, X-Ray; Enzyme Inhibitors/chemistry; Humans; Mice; Protein Conformation; Structure-Activity Relationship; Thiamine/chemistry; Thiamine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiamine / Transketolase / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: United States

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