Pharmacokinetic properties of TDP4815 after single intravenous and oral administrations to rat, rabbit, monkey, dog and in vitro drug metabolism.

Chen, Yanmin; Cheng, Deping; Tio, Cesar; Kagan, Natashia; Eisennagel, Stephen; Dasgupta, Malini; Tomczuk, Bruce; Bone, Roger; Huebert, Norman

Chen, Yanmin; Cheng, Deping; Tio, Cesar; Kagan, Natashia; Eisennagel, Stephen; Dasgupta, Malini; Tomczuk, Bruce; Bone, Roger; Huebert, Norman.

Affiliation

Chen Y; Johnson & Johnson Pharmaceutical Research and Development, Welsh & McKean Roads, Spring House, PA 19477, USA. ychen13@prdus.jnj.com

Biopharm Drug Dispos ; 29(3): 127-38, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18186144

Subject(s)

Anticoagulants/pharmacokinetics; Guanidine/analogs & derivatives; Administration, Oral; Animals; Anticoagulants/administration & dosage; Biological Availability; Body Weight; Dogs; Glucuronides/metabolism; Guanidine/administration & dosage; Guanidine/pharmacokinetics; Humans; In Vitro Techniques; Injections, Intravenous; Liver/blood supply; Liver/metabolism; Macaca fascicularis; Male; Microsomes, Liver/metabolism; Protein Binding; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Guanidine / Anticoagulants Limits: Animals / Humans / Male Language: En Journal: Biopharm Drug Dispos Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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