The influence of age on intestinal dipeptidyl peptidase IV (DPP IV/CD26), disaccharidases, and alkaline phosphatase enzyme activity in C57BL/6 mice.
Exp Aging Res
; 34(1): 49-62, 2008.
Article
in En
| MEDLINE
| ID: mdl-18189167
ABSTRACT
The objective of this study was to determine and describe the age-related changes in intestinal brush border membrane enzyme activities that occur in C57Bl/6 mice. Specifically, jejunal, duodenal, and ileal dipeptidyl peptidase IV/CD26, disaccharidase (lactase, sucrase, and maltase), and alkaline phosphatase activities were determined. A significant correlation between analyzed intestinal brush border membrane enzyme activities and animal age was found. Our study revealed that intestinal dipeptidyl peptidase IV/CD26, lactase, sucrase, maltase, and alkaline phosphatase activities decline significantly with age (p < .05). Nevertheless, the horizontal (duodenum to ileum) enzyme activity patterns are not affected by age.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Dipeptidyl Peptidase 4
/
Disaccharidases
/
Alkaline Phosphatase
/
Intestinal Mucosa
Limits:
Animals
Language:
En
Journal:
Exp Aging Res
Year:
2008
Document type:
Article
Affiliation country:
Croatia