Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder.
Acta Psychiatr Scand
; 117(4): 283-8, 2008 Apr.
Article
in En
| MEDLINE
| ID: mdl-18205896
ABSTRACT
OBJECTIVE:
Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N-acetyl-aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent.METHOD:
N-acetyl-aspartate, choline (Cho), creatine (Cr) and myo-inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated.RESULTS:
Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen.CONCLUSION:
We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bipolar Disorder
/
Choline
/
Aspartic Acid
/
Dysthymic Disorder
/
Creatine
/
Hippocampus
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Inositol
Limits:
Adult
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Female
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Humans
/
Male
Language:
En
Journal:
Acta Psychiatr Scand
Year:
2008
Document type:
Article
Affiliation country:
Germany