The selective oestrogen receptor modulator, LY362321, is not neuroprotective in a rat model of transient focal ischaemia.

Farr, T D; Carswell, H V O; McCann, D J; Sato, M; Bryant, H U; Dodge, J A; Macrae, I M

Farr, T D; Carswell, H V O; McCann, D J; Sato, M; Bryant, H U; Dodge, J A; Macrae, I M.

Affiliation

Farr TD; Wellcome Surgical Institute and 7T MRI Facility, Division of Clinical Neuroscience, University of Glasgow, Glasgow, UK. tracy.farr@nf.mpg.de

J Neuroendocrinol ; 20(3): 366-74, 2008 Mar.

Article in En | MEDLINE | ID: mdl-18208545

Subject(s)

Ischemic Attack, Transient/pathology; Selective Estrogen Receptor Modulators/pharmacology; Animals; Behavior, Animal/drug effects; Bone and Bones/drug effects; Central Nervous System/blood supply; Central Nervous System/drug effects; Cerebrovascular Circulation/drug effects; Cerebrovascular Circulation/physiology; Cerebrovascular Disorders/pathology; Disease Models, Animal; Drug Evaluation, Preclinical; Estradiol/pharmacology; Estrogen Antagonists/pharmacology; Female; Humans; Neuroprotective Agents/pharmacology; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen/antagonists & inhibitors; Receptors, Estrogen/metabolism; Selective Estrogen Receptor Modulators/pharmacokinetics; Tumor Cells, Cultured; Uterus/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ischemic Attack, Transient / Selective Estrogen Receptor Modulators Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Neuroendocrinol Journal subject: ENDOCRINOLOGIA / NEUROLOGIA Year: 2008 Document type: Article Affiliation country: United kingdom Country of publication: United States

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