MDC/CCL22 intrathecal levels in patients with multiple sclerosis.
Mult Scler
; 14(4): 547-9, 2008 May.
Article
in En
| MEDLINE
| ID: mdl-18208895
ABSTRACT
MDC/CCL22 has been detected in the brain of mice with experimental autoimmune encephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiple sclerosis (MS) and in 17 controls. No significant differences were found, even when stratifying patients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22 levels were observed in female patients when compared with female controls and male patients (109.03 versus 98.54 and 99.37 pg/mL, P = 0.034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sex Characteristics
/
Chemokine CCL22
/
Multiple Sclerosis
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2008
Document type:
Article
Affiliation country:
Italy