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The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.
Polli, Joseph W; Humphreys, Joan E; Harmon, Kelly A; Castellino, Stephen; O'Mara, Michael J; Olson, Katie L; John-Williams, Lisa St; Koch, Kevin M; Serabjit-Singh, Cosette J.
Affiliation
  • Polli JW; Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Inc., P.O. Box 13398, Room MAI.A2213, Research Triangle Park, NC 27709, USA. joseph.w.polli@gsk.com
Drug Metab Dispos ; 36(4): 695-701, 2008 Apr.
Article in En | MEDLINE | ID: mdl-18216274
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Quinazolines Limits: Animals / Humans / Male Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Quinazolines Limits: Animals / Humans / Male Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States