Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).

Yun, Nadezhda E; Linde, Nathaniel S; Zacks, Michele A; Barr, Ian G; Hurt, Aeron C; Smith, Jeanon N; Dziuba, Natallia; Holbrook, Michael R; Zhang, Lifang; Kilpatrick, John M; Arnold, C Shane; Paessler, Slobodan

Yun, Nadezhda E; Linde, Nathaniel S; Zacks, Michele A; Barr, Ian G; Hurt, Aeron C; Smith, Jeanon N; Dziuba, Natallia; Holbrook, Michael R; Zhang, Lifang; Kilpatrick, John M; Arnold, C Shane; Paessler, Slobodan.

Affiliation

Yun NE; Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Virology ; 374(1): 198-209, 2008 Apr 25.

Article in En | MEDLINE | ID: mdl-18234269

Subject(s)

Antiviral Agents/therapeutic use; Cyclopentanes/therapeutic use; Guanidines/therapeutic use; Influenza A Virus, H5N1 Subtype/drug effects; Orthomyxoviridae Infections/drug therapy; Acids, Carbocyclic; Animals; Cyclopentanes/administration & dosage; Ferrets; Guanidines/administration & dosage; Injections, Intramuscular; Lung/virology; Mice; Orthomyxoviridae Infections/pathology; Orthomyxoviridae Infections/physiopathology; Orthomyxoviridae Infections/virology; Oseltamivir/therapeutic use; Survival Analysis; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Orthomyxoviridae Infections / Cyclopentanes / Influenza A Virus, H5N1 Subtype / Guanidines Limits: Animals Language: En Journal: Virology Year: 2008 Document type: Article Affiliation country: United States

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