Case-control breast cancer study of MALDI-TOF proteomic mass spectrometry data on serum samples.
Stat Appl Genet Mol Biol
; 7(2): Article2, 2008.
Article
in En
| MEDLINE
| ID: mdl-18241195
ABSTRACT
We introduce mass spectrometry proteomic research for diagnosis from a clinical perspective, with special reference to early-stage breast cancer detection. The nature of SELDI and MALDI mass spectrometric measurement is discussed. We explain how the mass spectral data arising from this technology may be viewed as a new data type. Some of the properties of the data are discussed and we show how such spectra may be interpreted. Sample preprocessing for mass spectrometry is introduced and a literature review of research in clinical proteomics is presented. Finally, we provide a detailed description of the study design on the breast cancer case-control study which is investigated in this special issue.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Biomarkers, Tumor
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Stat Appl Genet Mol Biol
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA
Year:
2008
Document type:
Article