Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.

Travins, Jeremy M; Ali, Farah; Huang, Hui; Ballentine, Shelley K; Khalil, Ehab; Hufnagel, Heather R; Pan, Wenxi; Gushue, Joan; Leonard, Kristi; Bone, Roger F; Soll, Richard M; DesJarlais, Renee L; Crysler, Carl S; Ninan, Nisha; Kirkpatrick, Jennifer; Cummings, Maxwell D; Huebert, Norman; Molloy, Christopher J; Gaul, Michael; Tomczuk, Bruce E; Subasinghe, Nalin L

Travins, Jeremy M; Ali, Farah; Huang, Hui; Ballentine, Shelley K; Khalil, Ehab; Hufnagel, Heather R; Pan, Wenxi; Gushue, Joan; Leonard, Kristi; Bone, Roger F; Soll, Richard M; DesJarlais, Renee L; Crysler, Carl S; Ninan, Nisha; Kirkpatrick, Jennifer; Cummings, Maxwell D; Huebert, Norman; Molloy, Christopher J; Gaul, Michael; Tomczuk, Bruce E; Subasinghe, Nalin L.

Affiliation

Travins JM; Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 665 Stockton Drive, Exton, PA 19341, USA.

Bioorg Med Chem Lett ; 18(5): 1603-6, 2008 Mar 01.

Article in En | MEDLINE | ID: mdl-18242991

Subject(s)

Complement C1s/antagonists & inhibitors; Heterocyclic Compounds/chemistry; Heterocyclic Compounds/pharmacology; Animals; Binding Sites; Half-Life; Models, Molecular; Molecular Structure; Rats; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement C1s / Heterocyclic Compounds Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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