Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer.

Dorsey, Bruce D; Iqbal, Mohamed; Chatterjee, Sankar; Menta, Ernesto; Bernardini, Raffaella; Bernareggi, Alberto; Cassarà, Paolo G; D'Arasmo, Germano; Ferretti, Edmondo; De Munari, Sergio; Oliva, Ambrogio; Pezzoni, Gabriella; Allievi, Cecilia; Strepponi, Ivan; Ruggeri, Bruce; Ator, Mark A; Williams, Michael; Mallamo, John P

Dorsey, Bruce D; Iqbal, Mohamed; Chatterjee, Sankar; Menta, Ernesto; Bernardini, Raffaella; Bernareggi, Alberto; Cassarà, Paolo G; D'Arasmo, Germano; Ferretti, Edmondo; De Munari, Sergio; Oliva, Ambrogio; Pezzoni, Gabriella; Allievi, Cecilia; Strepponi, Ivan; Ruggeri, Bruce; Ator, Mark A; Williams, Michael; Mallamo, John P.

Affiliation

Dorsey BD; Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380, USA. bdorsey@cephalon.com

J Med Chem ; 51(4): 1068-72, 2008 Feb 28.

Article in En | MEDLINE | ID: mdl-18247547

Subject(s)

Antineoplastic Agents/chemical synthesis; Proteasome Inhibitors; Administration, Oral; Animals; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Mice; Neoplasm Transplantation; Proteasome Endopeptidase Complex/chemistry; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteasome Inhibitors / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States

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