Absorption of vaginal estrogen cream during sexual intercourse: a prospective, randomized, controlled trial.
J Reprod Med
; 53(1): 29-32, 2008 Jan.
Article
in En
| MEDLINE
| ID: mdl-18251358
ABSTRACT
OBJECTIVE:
To determine if intercourse changed serum estradiol levels in women using vaginal E2 cream or in their male partners. STUDYDESIGN:
Prospective, randomized, placebo-controlled, crossover, blinded study of 10 postmenopausal women and their male sexual partners. Subjects were randomized to estradiol or placebo cream and intercourse, then crossed over after 7-14 days. Seven to 14 days later, the woman used vaginal estradiol cream and abstained from intercourse. Serum E2 levels were obtained 10-12 hours after each exposure.RESULTS:
Serum E2 levels were higher in 8 of 10 men after intercourse with vaginal estradiol cream, and this resulted in a small but significant (p = 0.03) increase in the estradiol levels as compared to placebo. Paradoxically, intercourse resulted in markedly lower estradiol levels in women as compared to abstinence (p = 0.004).CONCLUSION:
Men absorb vaginal estradiol during intercourse, whereas intercourse reduces estradiol absorption in women. Although serum estradiol levels were only mildly elevated in men, it is possible that long-term exposure could cause feminizing changes. In women, estradiol levels were markedly reduced by intercourse.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coitus
/
Contraceptive Agents
/
Absorption
/
Estradiol
/
Estrogens
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Reprod Med
Year:
2008
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA