Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis.

Gutiérrez, Laura; Tsukamoto, Saho; Suzuki, Mikiko; Yamamoto-Mukai, Harumi; Yamamoto, Masayuki; Philipsen, Sjaak; Ohneda, Kinuko

Gutiérrez, Laura; Tsukamoto, Saho; Suzuki, Mikiko; Yamamoto-Mukai, Harumi; Yamamoto, Masayuki; Philipsen, Sjaak; Ohneda, Kinuko.

Affiliation

Gutiérrez L; Department of Cell Biology, Erasmus Medical College, Rotterdam, The Netherlands.

Blood ; 111(8): 4375-85, 2008 Apr 15.

Article in En | MEDLINE | ID: mdl-18258797

Subject(s)

Anemia, Aplastic/genetics; Erythropoiesis; GATA1 Transcription Factor/deficiency; Gene Deletion; Animals; Animals, Newborn; Bone Marrow Cells/drug effects; Bone Marrow Cells/pathology; Cell Count; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Erythroid Cells/drug effects; Erythroid Cells/pathology; Erythropoiesis/drug effects; Integrases/metabolism; Interferons/pharmacology; Megakaryocytes/drug effects; Megakaryocytes/pathology; Mice; Models, Biological; Spleen/drug effects; Spleen/pathology; Tamoxifen/pharmacology; Thrombocytopenia/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Deletion / Erythropoiesis / GATA1 Transcription Factor / Anemia, Aplastic Type of study: Prognostic_studies Limits: Animals Language: En Journal: Blood Year: 2008 Document type: Article Affiliation country: Netherlands Country of publication: United States

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