Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation.

Hirata, Yuki; Masuda, Yutaka; Kakutani, Hideki; Higuchi, Toshiyuki; Takada, Kimihiko; Ito, Akira; Nakagawa, Yoshio; Ishii, Hidemi

Hirata, Yuki; Masuda, Yutaka; Kakutani, Hideki; Higuchi, Toshiyuki; Takada, Kimihiko; Ito, Akira; Nakagawa, Yoshio; Ishii, Hidemi.

Affiliation

Hirata Y; Department of Molecular and Cellular Pathophysiology, Showa Pharmaceutical University, Higashi Tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.

Biochem Pharmacol ; 75(7): 1504-14, 2008 Apr 01.

Article in En | MEDLINE | ID: mdl-18261712

Subject(s)

Flavones/pharmacology; Monocytes/metabolism; NF-kappa B/antagonists & inhibitors; Sp1 Transcription Factor/antagonists & inhibitors; Thromboplastin/biosynthesis; Transcription Factor AP-1/antagonists & inhibitors; Animals; Cells, Cultured; Citrus; Flavones/isolation & purification; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Humans; Lipopolysaccharides/pharmacology; Monocytes/drug effects; NF-kappa B/metabolism; Plant Extracts/isolation & purification; Plant Extracts/pharmacology; Rabbits; Sp1 Transcription Factor/metabolism; Thromboplastin/genetics; Transcription Factor AP-1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thromboplastin / Monocytes / NF-kappa B / Sp1 Transcription Factor / Transcription Factor AP-1 / Flavones Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2008 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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