The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.

Kim, Yun-Gi; Park, Jong-Hwan; Shaw, Michael H; Franchi, Luigi; Inohara, Naohiro; Núñez, Gabriel

Kim, Yun-Gi; Park, Jong-Hwan; Shaw, Michael H; Franchi, Luigi; Inohara, Naohiro; Núñez, Gabriel.

Affiliation

Kim YG; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Immunity ; 28(2): 246-57, 2008 Feb.

Article in En | MEDLINE | ID: mdl-18261938

Subject(s)

Listeriosis/immunology; Macrophages/immunology; Nod1 Signaling Adaptor Protein/metabolism; Nod2 Signaling Adaptor Protein/metabolism; Toll-Like Receptors/metabolism; Acetylmuramyl-Alanyl-Isoglutamine/immunology; Animals; Cytokines/immunology; Cytokines/metabolism; Cytosol/immunology; Cytosol/metabolism; Escherichia coli/immunology; Intracellular Signaling Peptides and Proteins; Ligands; Lipopolysaccharides/immunology; Listeria monocytogenes/immunology; Macrophage Activation; Macrophages/metabolism; Mice; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/metabolism; Nod1 Signaling Adaptor Protein/immunology; Nod2 Signaling Adaptor Protein/immunology; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism; Signal Transduction; Toll-Like Receptors/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toll-Like Receptors / Nod1 Signaling Adaptor Protein / Nod2 Signaling Adaptor Protein / Listeriosis / Macrophages Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States

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