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Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.
Hernández, Andrés S; Swartz, Stephen G; Slusarchyk, Dorothy; Yan, Mujing; Seethala, R Krishna; Sleph, Paul; Grover, Gary; Dickinson, Kenneth; Giupponi, Leah; Harper, Timothy W; Humphreys, W Griffith; Longhi, Daniel A; Flynn, Neil; Murphy, Brian J; Gordon, David A; Biller, Scott A; Robl, Jeffrey A; Tino, Joseph A.
Affiliation
  • Hernández AS; Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA. andres.hernandez@bms.com
Bioorg Med Chem Lett ; 18(6): 2067-72, 2008 Mar 15.
Article in En | MEDLINE | ID: mdl-18282707
ABSTRACT
1H-tetrazole-1-alkanenitrile SR-9g exhibits a >10-fold in vivo potency enhancement over the lead nitrile 1 and has acceptable oral bioavailability in rats and dogs. An enantiospecific synthesis of 1H-tetrazole-1-alkanenitrile nitriles 9 has been developed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrazoles / Growth Hormone / Nitriles Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrazoles / Growth Hormone / Nitriles Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: United States