Besides adhesion: new perspectives of integrin functions in angiogenesis.
Cardiovasc Res
; 78(2): 213-22, 2008 May 01.
Article
in En
| MEDLINE
| ID: mdl-18285512
ABSTRACT
During angiogenic remodelling in embryo and adult life, endothelial cells lining blood vessel walls dynamically modify their integrin-mediated adhesive contacts with the surrounding extracellular matrix. However, besides regulating cell adhesion and migration, integrins dynamically participate in a network with soluble molecules and their receptors. Angiogenesis is characterized by opposing autocrine and paracrine loops of growth factors and semaphorins that regulate the activation of integrins on the endothelial surface through tyrosine kinase receptors (TKR) and the neuropilin/plexin system. Moreover, pro- and anti-angiogenic factors can directly bind integrins and regulate endothelial cell behaviour. This review summarizes the recent progress in understanding the reciprocal interactions between integrins, TKR, and semaphorin receptors.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Integrins
/
Cell Adhesion
/
Neovascularization, Physiologic
/
Endothelial Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
Cardiovasc Res
Year:
2008
Document type:
Article
Affiliation country:
Italy