Electrospray tandem mass spectrometric analysis of novel synthetic quinoxalinone derivatives.
Rapid Commun Mass Spectrom
; 22(6): 819-33, 2008.
Article
in En
| MEDLINE
| ID: mdl-18286668
ABSTRACT
Electrospray ionization tandem mass spectrometry (ESI-MS/MS) using a hybrid QqToF-MS/MS instrument has aided the structural characterization and differentiation of a novel series of medicinal synthetic 1-N-glycoside-quinoxalinone derivatives. These derivatives 7 and 8 are formed by an amino bond between the cyclic N-1 of the quinoxaline moiety and the C-6 position of a fully protected methyl or allyl alpha-D-mannofuranoside 3 and 4, and subsequent deprotection of the mannopyranoside moiety. In general the novel synthetic quinoxaline derivatives afforded the protonated molecules in ESI. The breakdown routes of the protonated molecules were rationalized by conducting low-energy CID-MS/MS analyses. In addition, re-confirmation of the various established fragmentation routes was achieved by conducting a series of ESI-CID-QqTof-MS/MS product ion scans on various selected precursor ions, which were initiated by CID in the atmospheric pressure/vacuum interface using a higher declustering potential. ESI-QqToF-MS/MS analysis has proven to be a specific and very sensitive method for the structural identification in the gas phase of these novel glycoquinoxalinamine derivatives.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinoxalines
/
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/
Spectrometry, Mass, Electrospray Ionization
Type of study:
Diagnostic_studies
/
Prognostic_studies
Language:
En
Journal:
Rapid Commun Mass Spectrom
Year:
2008
Document type:
Article
Affiliation country:
France