Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant.

Cossette, Chantal; Patel, Pranav; Anumolu, Jaganmohan R; Sivendran, Sashikala; Lee, Gue Jae; Gravel, Sylvie; Graham, François D; Lesimple, Alain; Mamer, Orval A; Rokach, Joshua; Powell, William S

Cossette, Chantal; Patel, Pranav; Anumolu, Jaganmohan R; Sivendran, Sashikala; Lee, Gue Jae; Gravel, Sylvie; Graham, François D; Lesimple, Alain; Mamer, Orval A; Rokach, Joshua; Powell, William S.

Affiliation

Cossette C; Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec H2X 2P2, Canada.

J Biol Chem ; 283(17): 11234-43, 2008 Apr 25.

Article in En | MEDLINE | ID: mdl-18287092

Subject(s)

Fatty Acids, Unsaturated/metabolism; Granulocytes/metabolism; Linoleic Acids/metabolism; Neutrophils/metabolism; Sebum/metabolism; Calcium/metabolism; Chemotactic Factors/metabolism; Chemotaxis; Humans; Hydroxyeicosatetraenoic Acids/chemistry; Inflammation; Keratinocytes/metabolism; Models, Chemical; NADP/chemistry; Skin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sebum / Linoleic Acids / Fatty Acids, Unsaturated / Granulocytes / Neutrophils Type of study: Guideline / Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2008 Document type: Article Affiliation country: Canada

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