The host complement system and arbovirus pathogenesis.
Curr Drug Targets
; 9(2): 165-72, 2008 Feb.
Article
in En
| MEDLINE
| ID: mdl-18288968
ABSTRACT
Arthropod-borne viruses (arboviruses) are a significant cause of human diseases worldwide. Interactions between these viruses and the innate immune system play a major role in determining the outcome of disease. The complement system is particularly important in this process as activation of complement can contribute to both host defense as well as injury to host tissues. This review focuses on the increasing evidence that the complement system plays key roles in both protective and pathologic outcomes of arbovirus infection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arbovirus Infections
/
Arboviruses
/
Complement Activation
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Curr Drug Targets
Journal subject:
TERAPIA POR MEDICAMENTOS
Year:
2008
Document type:
Article
Affiliation country:
United States