Administration, Intranasal; Antineoplastic Agents/administration & dosage; Brain Neoplasms/drug therapy; Glioma/drug therapy; Monoterpenes/administration & dosage; Antineoplastic Agents, Alkylating/administration & dosage; Blood-Brain Barrier/drug effects; Blood-Brain Barrier/physiology; Brain Neoplasms/metabolism; Brain Neoplasms/physiopathology; Dacarbazine/administration & dosage; Dacarbazine/analogs & derivatives; Disease Progression; Drug Administration Schedule; Enzyme Inhibitors/administration & dosage; Female; Glioma/metabolism; Glioma/physiopathology; Humans; Magnetic Resonance Imaging; Male; Neoplasm Recurrence, Local/drug therapy; Neoplasm Recurrence, Local/metabolism; Neoplasm Recurrence, Local/physiopathology; Oncogene Protein p21(ras)/drug effects; Oncogene Protein p21(ras)/genetics; Oncogene Protein p21(ras)/metabolism; Signal Transduction/drug effects; Signal Transduction/physiology; Survival Rate; Temozolomide; Transforming Growth Factor beta/drug effects; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism; Treatment Outcome