Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues.

Zanardi, Franca; Burreddu, Paola; Rassu, Gloria; Auzzas, Luciana; Battistini, Lucia; Curti, Claudio; Sartori, Andrea; Nicastro, Giuseppe; Menchi, Gloria; Cini, Nicoletta; Bottoncetti, Anna; Bottonocetti, Anna; Raspanti, Silvia; Casiraghi, Giovanni

Zanardi, Franca; Burreddu, Paola; Rassu, Gloria; Auzzas, Luciana; Battistini, Lucia; Curti, Claudio; Sartori, Andrea; Nicastro, Giuseppe; Menchi, Gloria; Cini, Nicoletta; Bottoncetti, Anna; Bottonocetti, Anna; Raspanti, Silvia; Casiraghi, Giovanni.

Affiliation

Zanardi F; Dipartimento Farmaceutica, Università di Parma, Viale G.P. Usberti 27A, Parma, Italy. franca.zanardi@unipr.it

J Med Chem ; 51(6): 1771-82, 2008 Mar 27.

Article in En | MEDLINE | ID: mdl-18303826

Subject(s)

Integrin alphaVbeta3/drug effects; Integrins/drug effects; Oligopeptides/pharmacology; Proline/analogs & derivatives; Proline/chemistry; Receptors, Vitronectin/drug effects; Binding Sites; Crystallography, X-Ray; Humans; Integrin alphaVbeta3/chemistry; Integrins/chemistry; Magnetic Resonance Spectroscopy/methods; Models, Molecular; Molecular Structure; Oligopeptides/chemistry; Receptors, Vitronectin/chemistry; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Proline / Integrins / Receptors, Vitronectin / Integrin alphaVbeta3 Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Document type: Article Affiliation country: Italy Country of publication: United States

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