Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists.

Lai, Gaifa; Merritt, J Robert; He, Zhenmin; Feng, Daming; Chao, Jianhua; Czarniecki, Michael F; Rokosz, Laura L; Stauffer, Tara M; Rindgen, Diane; Taveras, Arthur G

Lai, Gaifa; Merritt, J Robert; He, Zhenmin; Feng, Daming; Chao, Jianhua; Czarniecki, Michael F; Rokosz, Laura L; Stauffer, Tara M; Rindgen, Diane; Taveras, Arthur G.

Affiliation

Lai G; Pharmacopeia, Inc., 3000 Eastpark Boulevard, Cranbury, NJ 08512, USA. galai@pcop.com

Bioorg Med Chem Lett ; 18(6): 1864-8, 2008 Mar 15.

Article in En | MEDLINE | ID: mdl-18304809

Subject(s)

Cyclobutanes/chemical synthesis; Cyclobutanes/pharmacology; Receptors, Interleukin-8B/antagonists & inhibitors; Administration, Oral; Animals; Biological Availability; Cyclobutanes/chemistry; Haplorhini; Molecular Structure; Protein Binding; Rats; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclobutanes / Receptors, Interleukin-8B Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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