Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells.

Kim, Dong Hyun; Burgess, Angela P; Li, Ming; Tsenovoy, Peter L; Addabbo, Francesco; McClung, John A; Puri, Nitin; Abraham, Nader G

Kim, Dong Hyun; Burgess, Angela P; Li, Ming; Tsenovoy, Peter L; Addabbo, Francesco; McClung, John A; Puri, Nitin; Abraham, Nader G.

Affiliation

Kim DH; Dept. of Pharmacology, New York Medical College, Valhalla, NY 10595, USA.

J Pharmacol Exp Ther ; 325(3): 833-40, 2008 Jun.

Article in En | MEDLINE | ID: mdl-18334666

Subject(s)

Adipogenesis; Adiponectin/blood; Heme Oxygenase-1/metabolism; Mesenchymal Stem Cells/metabolism; Obesity/metabolism; Adipocytes/cytology; Adipocytes/drug effects; Adipogenesis/drug effects; Animals; Aorta/drug effects; Aorta/metabolism; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Type 2/metabolism; Humans; Interleukin-6/metabolism; Kidney/drug effects; Kidney/metabolism; Male; Mesenchymal Stem Cells/drug effects; Metalloporphyrins/pharmacology; Myocardium/metabolism; Protoporphyrins/pharmacology; Rats; Rats, Zucker; Superoxides/metabolism; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adiponectin / Heme Oxygenase-1 / Adipogenesis / Mesenchymal Stem Cells / Obesity Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States

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