Human IgG2 antibodies display disulfide-mediated structural isoforms.

Wypych, Jette; Li, Ming; Guo, Amy; Zhang, Zhongqi; Martinez, Theresa; Allen, Martin J; Fodor, Szilan; Kelner, Drew N; Flynn, Gregory C; Liu, Yaoqing Diana; Bondarenko, Pavel V; Ricci, Margaret Speed; Dillon, Thomas M; Balland, Alain

Wypych, Jette; Li, Ming; Guo, Amy; Zhang, Zhongqi; Martinez, Theresa; Allen, Martin J; Fodor, Szilan; Kelner, Drew N; Flynn, Gregory C; Liu, Yaoqing Diana; Bondarenko, Pavel V; Ricci, Margaret Speed; Dillon, Thomas M; Balland, Alain.

Affiliation

Wypych J; Department of Analytical Sciences, Amgen Inc., Thousand Oaks, California 91320, USA. jwypych@amgen.com

J Biol Chem ; 283(23): 16194-205, 2008 Jun 06.

Article in En | MEDLINE | ID: mdl-18339624

Subject(s)

Disulfides/chemistry; Immunoglobulin G/chemistry; Immunoglobulin kappa-Chains/chemistry; Immunoglobulin lambda-Chains/chemistry; Humans; Immunoglobulin G/genetics; Immunoglobulin kappa-Chains/genetics; Immunoglobulin lambda-Chains/genetics; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Structure, Quaternary/physiology; Recombinant Proteins/chemistry; Recombinant Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin kappa-Chains / Immunoglobulin lambda-Chains / Disulfides Limits: Humans Language: En Journal: J Biol Chem Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States

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