Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines.

Hallifax, D; Galetin, A; Houston, J B

Hallifax, D; Galetin, A; Houston, J B.

Affiliation

Hallifax D; Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.

Xenobiotica ; 38(4): 353-67, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18340561

Subject(s)

Benzodiazepines/pharmacokinetics; Cryopreservation; Hepatocytes/metabolism; Microsomes, Liver/enzymology; Alprazolam/pharmacokinetics; Cell Survival; Cells, Cultured; Cytochrome P-450 CYP3A/metabolism; Diazepam/pharmacokinetics; Flunitrazepam/pharmacokinetics; Hepatocytes/cytology; Hepatocytes/enzymology; Humans; Metabolic Clearance Rate; Midazolam/pharmacokinetics; Substrate Specificity; Triazolam/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepines / Microsomes, Liver / Cryopreservation / Hepatocytes Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Xenobiotica Year: 2008 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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