Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding.

Richartz, Anja; Höltje, Monika; Brandt, Birte; Schäfer-Korting, Monika; Höltje, Hans-Dieter

Richartz, Anja; Höltje, Monika; Brandt, Birte; Schäfer-Korting, Monika; Höltje, Hans-Dieter.

Affiliation

Richartz A; Department of Pharmacology and Toxicology, Free University of Berlin, Berlin, Germany.

J Enzyme Inhib Med Chem ; 23(1): 94-100, 2008 Feb.

Article in En | MEDLINE | ID: mdl-18341260

Subject(s)

Cell Division/drug effects; DNA Polymerase I/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Keratinocytes/enzymology; Adenine/analogs & derivatives; Adenine/pharmacology; Antiviral Agents/pharmacology; Aphidicolin/pharmacology; Binding Sites; DNA Polymerase I/chemistry; Humans; Keratinocytes/drug effects; Ligands; Models, Biological; Models, Molecular; Organophosphonates/pharmacology; Protein Conformation; Reverse Transcriptase Inhibitors/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Keratinocytes / Cell Division / DNA Polymerase I / Enzyme Inhibitors Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: Germany

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