Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents.

Catalano, Alessia; Carocci, Alessia; Corbo, Filomena; Franchini, Carlo; Muraglia, Marilena; Scilimati, Antonio; De Bellis, Michela; De Luca, Annamaria; Camerino, Diana Conte; Sinicropi, Maria Stefania; Tortorella, Vincenzo

Catalano, Alessia; Carocci, Alessia; Corbo, Filomena; Franchini, Carlo; Muraglia, Marilena; Scilimati, Antonio; De Bellis, Michela; De Luca, Annamaria; Camerino, Diana Conte; Sinicropi, Maria Stefania; Tortorella, Vincenzo.

Affiliation

Catalano A; Department of Medicinal Chemistry, University of Bari, via E. Orabona n. 4, 70125 Bari, Italy.

Eur J Med Chem ; 43(11): 2535-40, 2008 Nov.

Article in En | MEDLINE | ID: mdl-18342401

Subject(s)

Muscle, Skeletal/drug effects; Myotonia; Sodium Channel Blockers/chemical synthesis; Sodium Channel Blockers/pharmacology; Tocainide/chemical synthesis; Tocainide/pharmacology; Molecular Structure; Muscle, Skeletal/metabolism; Sodium Channel Blockers/chemistry; Structure-Activity Relationship; Tocainide/analogs & derivatives; Tocainide/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tocainide / Muscle, Skeletal / Sodium Channel Blockers / Myotonia Language: En Journal: Eur J Med Chem Year: 2008 Document type: Article Affiliation country: Italy Country of publication: France

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