Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.

Sun, Ying; Ren, Meng; Gao, Guan-qi; Gong, Bendi; Xin, Wei; Guo, Hua; Zhang, Xiu-juan; Gao, Ling; Zhao, Jia-jun

Sun, Ying; Ren, Meng; Gao, Guan-qi; Gong, Bendi; Xin, Wei; Guo, Hua; Zhang, Xiu-juan; Gao, Ling; Zhao, Jia-jun.

Affiliation

Sun Y; Department of Endocrinology, Shandong University, Jinan 250021, China.

Acta Pharmacol Sin ; 29(4): 443-50, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18358090

Subject(s)

AMP-Activated Protein Kinases/antagonists & inhibitors; Fenofibrate/pharmacology; Insulin-Secreting Cells/drug effects; Insulin/metabolism; PPAR alpha/metabolism; Palmitates/pharmacology; Animals; Cell Culture Techniques; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Glucose/pharmacology; Insulin Secretion; Insulin-Secreting Cells/metabolism; Insulinoma/metabolism; Islets of Langerhans/cytology; Islets of Langerhans/drug effects; Islets of Langerhans/physiology; Luminescence; Luminescent Measurements; Male; Rats; Rats, Wistar

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Palmitates / Fenofibrate / PPAR alpha / Insulin-Secreting Cells / AMP-Activated Protein Kinases / Insulin Limits: Animals Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2008 Document type: Article Affiliation country: China Country of publication: United States

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