Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.

Starck, Jean-Philippe; Provins, Laurent; Christophe, Bernard; Gillard, Michel; Jadot, Sophie; Lo Brutto, Patrick; Quéré, Luc; Talaga, Patrice; Guyaux, Michel

Starck, Jean-Philippe; Provins, Laurent; Christophe, Bernard; Gillard, Michel; Jadot, Sophie; Lo Brutto, Patrick; Quéré, Luc; Talaga, Patrice; Guyaux, Michel.

Affiliation

Starck JP; UCB, R&D, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium.

Bioorg Med Chem Lett ; 18(8): 2675-8, 2008 Apr 15.

Article in En | MEDLINE | ID: mdl-18359633

Subject(s)

Alkynes/chemistry; Muscarinic Antagonists/chemical synthesis; Muscarinic Antagonists/pharmacology; Pulmonary Disease, Chronic Obstructive/drug therapy; Quinuclidines/chemical synthesis; Quinuclidines/pharmacology; Cholinergic Antagonists/chemistry; Molecular Structure; Muscarinic Antagonists/chemistry; Muscarinic Antagonists/therapeutic use; Quinuclidines/chemistry; Quinuclidines/therapeutic use; Receptor, Muscarinic M2/metabolism; Receptor, Muscarinic M3/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinuclidines / Muscarinic Antagonists / Pulmonary Disease, Chronic Obstructive / Alkynes Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: Belgium Country of publication: United kingdom

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