Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.
J Virol
; 82(11): 5631-5, 2008 Jun.
Article
in En
| MEDLINE
| ID: mdl-18367519
ABSTRACT
Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Replication
/
Histocompatibility Antigens Class I
/
Simian Acquired Immunodeficiency Syndrome
/
Simian Immunodeficiency Virus
/
CD8-Positive T-Lymphocytes
/
Epitopes, T-Lymphocyte
/
Macaca mulatta
Limits:
Animals
Language:
En
Journal:
J Virol
Year:
2008
Document type:
Article
Affiliation country:
United States