Transformation by bovine papillomavirus type 1 E6 requires paxillin.
J Virol
; 82(12): 5962-6, 2008 Jun.
Article
in En
| MEDLINE
| ID: mdl-18385245
ABSTRACT
Papillomavirus E6 proteins are adapters that change the function of cellular regulatory proteins. The bovine papillomavirus type 1 E6 (BE6) binds to LXXLL peptide sequences termed LD motifs (consensus sequence LDXLLXXL) on the cellular protein paxillin that is a substrate of Src and focal adhesion kinases. Anchorage-independent transformation induced by BE6 required both paxillin and BE6-binding LD motifs on paxillin but was independent of the major tyrosine phosphorylation sites of paxillin. The essential role of paxillin in transformation by BE6 highlights the role of paxillin in the transduction of cellular signals that result in anchorage-independent cell proliferation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Transformation, Viral
/
Paxillin
/
Bovine papillomavirus 1
Limits:
Animals
Language:
En
Journal:
J Virol
Year:
2008
Document type:
Article
Affiliation country:
United States