Dose-dependent thrombus resolution due to oral plaminogen activator inhibitor (PAI)-1 inhibition with tiplaxtinin in a rat stenosis model of venous thrombosis.

Baxi, Sanjiv; Crandall, David L; Meier, Thomas R; Wrobleski, Shirley; Hawley, Angela; Farris, Diana; Elokdah, Hassan; Sigler, Robert; Schaub, Robert G; Wakefield, Thomas; Myers, Daniel

Baxi, Sanjiv; Crandall, David L; Meier, Thomas R; Wrobleski, Shirley; Hawley, Angela; Farris, Diana; Elokdah, Hassan; Sigler, Robert; Schaub, Robert G; Wakefield, Thomas; Myers, Daniel.

Affiliation

Baxi S; Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0654, USA.

Thromb Haemost ; 99(4): 749-58, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18392333

Subject(s)

Indoleacetic Acids/administration & dosage; Plasminogen Activator Inhibitor 1/blood; Venous Thrombosis/blood; Venous Thrombosis/drug therapy; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enoxaparin/antagonists & inhibitors; Fibrosis; Inflammation/drug therapy; Inflammation/pathology; Male; Rats; Rats, Sprague-Dawley; Tunica Intima/pathology; Vena Cava, Inferior/pathology; Venous Thrombosis/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasminogen Activator Inhibitor 1 / Venous Thrombosis / Indoleacetic Acids Limits: Animals Language: En Journal: Thromb Haemost Year: 2008 Document type: Article Affiliation country: United States

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