Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility.
Neuron
; 58(1): 104-17, 2008 Apr 10.
Article
in En
| MEDLINE
| ID: mdl-18400167
ABSTRACT
While most studies have focused on the role of long-term potentiation in behavior, far less is known about the role of long-term depression (LTD). To examine the potential involvement of LTD in learning and memory, we generated transgenic mice that express a fragment of the SV40 small t antigen known to inhibit protein phosphatase 2A (PP2A). Small t antigen expression blocked both stimulus-induced and chemically induced NMDAR-dependent LTD at Schaffer collateral synapses but did not affect potentiation, depotentiation, or mGluR-dependent LTD. This physiological phenotype was associated with deficits in behavioral flexibility in both the Morris water maze and a delayed nonmatch to place T-maze task, suggesting that NMDAR-dependent LTD is required for behavioral flexibility and may act by weakening previously encoded memory traces when new information is learned.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, N-Methyl-D-Aspartate
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Maze Learning
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Long-Term Synaptic Depression
Limits:
Animals
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Humans
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Male
Language:
En
Journal:
Neuron
Journal subject:
NEUROLOGIA
Year:
2008
Document type:
Article
Affiliation country:
United States