Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei.
Exp Parasitol
; 119(2): 308-12, 2008 Jun.
Article
in En
| MEDLINE
| ID: mdl-18406406
ABSTRACT
The farnesyl diphosphate synthase (FPPS) has previously been characterized in trypanosomes as an essential enzyme for their survival and as the target for bisphosphonates, drugs that are effective both in vitro and in vivo against these parasites. Enzymes from the isoprenoid pathway have been assigned to different compartments in eukaryotes, including trypanosomatids. We here report that FPPS localizes to the cytoplasm of both Trypanosoma cruzi and T. brucei, and is not present in other organelles such as the mitochondria and glycosomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trypanosoma brucei brucei
/
Trypanosoma cruzi
/
Geranyltranstransferase
Limits:
Animals
Language:
En
Journal:
Exp Parasitol
Year:
2008
Document type:
Article
Affiliation country:
Sweden