Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.

Serova, Maria; Ghoul, Aïda; Benhadji, Karim A; Faivre, Sandrine; Le Tourneau, Christophe; Cvitkovic, Esteban; Lokiec, Francois; Lord, Janet; Ogbourne, Steven M; Calvo, Fabien; Raymond, Eric

Serova, Maria; Ghoul, Aïda; Benhadji, Karim A; Faivre, Sandrine; Le Tourneau, Christophe; Cvitkovic, Esteban; Lokiec, Francois; Lord, Janet; Ogbourne, Steven M; Calvo, Fabien; Raymond, Eric.

Affiliation

Serova M; Institut National de la Sante et de la Recherche Medicale-U728-RAYLAB and Department of Medical Oncology, Beaujon University Hospital, Clichy, France.

Mol Cancer Ther ; 7(4): 915-22, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18413805

Subject(s)

Colonic Neoplasms/metabolism; Diterpenes/pharmacology; Esters/pharmacology; Gene Expression Regulation, Neoplastic/drug effects; Mitogen-Activated Protein Kinases/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Protein Kinase C-alpha/metabolism; Protein Kinase C-delta/metabolism; Signal Transduction/drug effects; Apoptosis/drug effects; Blotting, Western; Colonic Neoplasms/pathology; Humans; JNK Mitogen-Activated Protein Kinases/metabolism; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; PTEN Phosphohydrolase/metabolism; Phosphorylation/drug effects; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/metabolism; Proto-Oncogene Proteins c-raf/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; S Phase/drug effects; Tumor Cells, Cultured; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Gene Expression Regulation, Neoplastic / Colonic Neoplasms / Phosphatidylinositol 3-Kinases / Mitogen-Activated Protein Kinases / Diterpenes / Esters / Protein Kinase C-alpha / Protein Kinase C-delta Limits: Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2008 Document type: Article Affiliation country: France Country of publication: United States

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