Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

Fisher, Sheila A; Tremelling, Mark; Anderson, Carl A; Gwilliam, Rhian; Bumpstead, Suzannah; Prescott, Natalie J; Nimmo, Elaine R; Massey, Dunecan; Berzuini, Carlo; Johnson, Christopher; Barrett, Jeffrey C; Cummings, Fraser R; Drummond, Hazel; Lees, Charlie W; Onnie, Clive M; Hanson, Catherine E; Blaszczyk, Katarzyna; Inouye, Mike; Ewels, Philip; Ravindrarajah, Radhi; Keniry, Andrew; Hunt, Sarah; Carter, Martyn; Watkins, Nick; Ouwehand, Willem; Lewis, Cathryn M; Cardon, Lon; Lobo, Alan; Forbes, Alastair; Sanderson, Jeremy; Jewell, Derek P; Mansfield, John C; Deloukas, Panos; Mathew, Christopher G; Parkes, Miles; Satsangi, Jack

Fisher, Sheila A; Tremelling, Mark; Anderson, Carl A; Gwilliam, Rhian; Bumpstead, Suzannah; Prescott, Natalie J; Nimmo, Elaine R; Massey, Dunecan; Berzuini, Carlo; Johnson, Christopher; Barrett, Jeffrey C; Cummings, Fraser R; Drummond, Hazel; Lees, Charlie W; Onnie, Clive M; Hanson, Catherine E; Blaszczyk, Katarzyna; Inouye, Mike; Ewels, Philip; Ravindrarajah, Radhi; Keniry, Andrew; Hunt, Sarah; Carter, Martyn; Watkins, Nick; Ouwehand, Willem; Lewis, Cathryn M; Cardon, Lon; Lobo, Alan; Forbes, Alastair; Sanderson, Jeremy; Jewell, Derek P; Mansfield, John C; Deloukas, Panos; Mathew, Christopher G; Parkes, Miles; Satsangi, Jack.

Affiliation

Fisher SA; Department of Medical and Molecular Genetics, King's College London School of Medicine, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, UK.

Nat Genet ; 40(6): 710-2, 2008 Jun.

Article in En | MEDLINE | ID: mdl-18438406

Subject(s)

Biomarkers/metabolism; Colitis, Ulcerative/genetics; Crohn Disease/genetics; Extracellular Matrix Proteins/genetics; Genetic Predisposition to Disease; Polymorphism, Single Nucleotide/genetics; Autophagy-Related Proteins; Carrier Proteins/genetics; Case-Control Studies; Cohort Studies; Colitis, Ulcerative/epidemiology; Crohn Disease/epidemiology; GTP-Binding Proteins/genetics; HLA-A Antigens/genetics; Homeodomain Proteins/genetics; Humans; Interleukin-12 Subunit p40/genetics; Intracellular Signaling Peptides and Proteins; Nod2 Signaling Adaptor Protein/genetics; Protein Serine-Threonine Kinases/genetics; Receptors, Interleukin/genetics; Risk Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Colitis, Ulcerative / Crohn Disease / Extracellular Matrix Proteins / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2008 Document type: Article Affiliation country: United kingdom Country of publication: United States

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