Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells.

Wu, Wei; Abraham, Linu; Ogony, Joshua; Matthews, Richard; Goldstein, Glenn; Ercal, Nuran

Wu, Wei; Abraham, Linu; Ogony, Joshua; Matthews, Richard; Goldstein, Glenn; Ercal, Nuran.

Affiliation

Wu W; Department of Chemistry, Missouri University of Science and Technology, 1870 Miner Circle, Rolla, MO 65409, USA.

Life Sci ; 82(21-22): 1122-30, 2008 May 23.

Article in En | MEDLINE | ID: mdl-18448127

Subject(s)

Acetylcysteine/analogs & derivatives; Antioxidants/pharmacology; Cell Survival/drug effects; Cell Survival/radiation effects; Radiation-Protective Agents; Acetylcysteine/pharmacology; Acetylcysteine/toxicity; Animals; Apoptosis/drug effects; Apoptosis/radiation effects; CHO Cells; Caspase 3/metabolism; Catalase/metabolism; Cell Proliferation/drug effects; Cell Proliferation/radiation effects; Cricetinae; Cricetulus; Cysteine/metabolism; Dose-Response Relationship, Drug; Glutathione/metabolism; Glutathione Peroxidase/metabolism; Glutathione Reductase/metabolism; Malondialdehyde/metabolism; Oxidative Stress/drug effects; Oxidative Stress/radiation effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Radiation-Protective Agents / Cell Survival / Antioxidants Limits: Animals Language: En Journal: Life Sci Year: 2008 Document type: Article Affiliation country: United States

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