Successful in vivo propagation of factor IX-producing hepatocytes in mice: potential for cell-based therapy in haemophilia B.

Tatsumi, Kohei; Ohashi, Kazuo; Kataoka, Miho; Tateno, Chise; Shibata, Masaru; Naka, Hiroyuki; Shima, Midori; Hisanaga, Michiyoshi; Kanehiro, Hiromichi; Okano, Teruo; Yoshizato, Katsutoshi; Nakajima, Yoshiyuki; Yoshioka, Akira

Tatsumi, Kohei; Ohashi, Kazuo; Kataoka, Miho; Tateno, Chise; Shibata, Masaru; Naka, Hiroyuki; Shima, Midori; Hisanaga, Michiyoshi; Kanehiro, Hiromichi; Okano, Teruo; Yoshizato, Katsutoshi; Nakajima, Yoshiyuki; Yoshioka, Akira.

Affiliation

Tatsumi K; Department of Pediatrics, Nara Medical University, Nara, Japan.

Thromb Haemost ; 99(5): 883-91, 2008 May.

Article in En | MEDLINE | ID: mdl-18449417

Subject(s)

Cell Transplantation/methods; Factor IX/metabolism; Hemophilia B/surgery; Hepatocytes/transplantation; Liver/surgery; Animals; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Child; Dogs; Factor IX/genetics; Female; Hemophilia B/metabolism; Hepatocytes/metabolism; Humans; Infant; Liver/metabolism; Liver/pathology; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Mice, Transgenic; RNA, Messenger/metabolism; Serum Albumin/metabolism; Time Factors; Transplantation, Heterologous; Urokinase-Type Plasminogen Activator/genetics; Urokinase-Type Plasminogen Activator/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Factor IX / Hemophilia B / Cell Transplantation / Hepatocytes / Liver Limits: Animals / Child / Female / Humans / Infant / Male Language: En Journal: Thromb Haemost Year: 2008 Document type: Article Affiliation country: Japan

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