Structural basis of DNA quadruplex recognition by an acridine drug.
J Am Chem Soc
; 130(21): 6722-4, 2008 May 28.
Article
in En
| MEDLINE
| ID: mdl-18457389
ABSTRACT
The crystal structure of a complex between the bimolecular human telomeric quadruplex d(TAGGGTTAGGGT)2 and the experimental anticancer drug BRACO-19, has been determined, to 2.5 A resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecules. The structure rationalizes the existing structure-activity data and provides a starting-point for the structure-based design of quadruplex-binding ligands
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acridines
/
DNA
/
G-Quadruplexes
Limits:
Humans
Language:
En
Journal:
J Am Chem Soc
Year:
2008
Document type:
Article
Affiliation country:
United kingdom
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA