In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.

Fineschi, Serena; Bongiovanni, Massimo; Donati, Yves; Djaafar, Souad; Naso, Filippo; Goffin, Laurence; Argiroffo, Constance Barazzone; Pache, Jean-Claude; Dayer, Jean-Michel; Ferrari-Lacraz, Sylvie; Chizzolini, Carlo

Fineschi, Serena; Bongiovanni, Massimo; Donati, Yves; Djaafar, Souad; Naso, Filippo; Goffin, Laurence; Argiroffo, Constance Barazzone; Pache, Jean-Claude; Dayer, Jean-Michel; Ferrari-Lacraz, Sylvie; Chizzolini, Carlo.

Affiliation

Fineschi S; Immunology and Allergy, Department of Internal Medicine, School of Medicine and University Hospital, Geneva, Switzerland.

Am J Respir Cell Mol Biol ; 39(4): 458-65, 2008 Oct.

Article in En | MEDLINE | ID: mdl-18458239

Subject(s)

Proteasome Inhibitors; Pulmonary Fibrosis/pathology; Scleroderma, Systemic/pathology; Animals; Bleomycin; Boronic Acids/pharmacology; Bortezomib; Cells, Cultured; Collagen Type I/metabolism; Fibrosis; Hydroxyproline/metabolism; Leupeptins/pharmacology; Lung/metabolism; Lung/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Serine-Threonine Kinases/genetics; Pulmonary Fibrosis/chemically induced; Pulmonary Fibrosis/metabolism; Pyrazines/pharmacology; Scleroderma, Systemic/genetics; Scleroderma, Systemic/metabolism; Signal Transduction; Skin/metabolism; Skin/pathology; Transforming Growth Factor beta/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Scleroderma, Systemic / Proteasome Inhibitors Limits: Animals Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2008 Document type: Article Affiliation country: Switzerland

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