Adult mesenchymal stromal stem cells for therapeutic applications.
Minim Invasive Ther Allied Technol
; 17(2): 79-90, 2008.
Article
in En
| MEDLINE
| ID: mdl-18465443
ABSTRACT
Mesenchymal stromal stem cells (MSC) can be found in almost any adult organ. They can be isolated and expanded within several weeks up to hundreds of millions of cells. The cell isolation based on the surface antigen expression may significantly enrich for the desired cell population and reduce the time required for cell expansion. MSC display a unique molecular signature which clearly discriminates them from other stem cell types. MSC can be differentiated into the cells of several lineages. Additionally, the unique biological properties of MSC are mediated by strong immunomodulatory activity and by paracrine mechanisms. Potential therapeutic applications of the cells require clinically compliant protocols for cell isolation and expansion. The therapeutic utility of MSC has been evaluated and found to be useful in several pre-clinical animal models as well as in clinical trials.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Culture Techniques
/
Mesenchymal Stem Cell Transplantation
/
Mesenchymal Stem Cells
Type of study:
Guideline
Limits:
Adult
/
Animals
/
Humans
Language:
En
Journal:
Minim Invasive Ther Allied Technol
Journal subject:
TERAPEUTICA
Year:
2008
Document type:
Article
Affiliation country:
Germany